ELF p 4 ^ 4 ( 4 4 IP IP IP IP 0 J J /usr/lib/ld.so.1 a z T \ E I @ S 3 D ( N W O p t y e v i < m n P o ' b G - Q w _ a . V f # j c ] l ^ * ` r g q M H X ! k = d [ R Z h L x 0 u s " 4 & ) ; 6 A F / : 8 9 K U 1 > % J Y B 7 + C 5 $ ? , 2 \ 8 P p 4
4 4 IP
Ip J KP Kl Kt K| K Uh Up
J< Ux p t U| " U ' J0 , J$ 1 U 6 U 8 U ( : l C U L `, Q - ` U e ^p @! j IP
U p 0 | U I I U U I U ( I V V - V 4
V h V P 4 $ Jl + 1 d 2 Vh 7 , 0 E - T Q Vl V J _ Vp g J n ^p @ t .x < ~ _ 0 ( @ I _ _ _ JT "P @ U ! J _ KX K` _ 2$ _ 1
J` K\ _ K % Ip ? J E J L IP S 4 ` JH g _ l _ o _ r _ ( u $ z . ` `$ - | Jx 4 ,l t `( I s12 betatot getopt xx _start cst nbar atof atoi epas P b init_cst _environ _end metrique_siman xs12 _iob __register_frame_info _GLOBAL_OFFSET_TABLE_ b_init recur_exhau randomMT tmax atexit exit graph exhau malloc tnv pow xr1 xr2 print_help emax _init test_param risk affiche beta eval_exhau sscanf seedMT emin energie_siman print_siman test _DYNAMIC fichier printf __iob print_err verb recur eval _exit ener d1 d2 exp exhaustive environ free optind fd nbar_limite nomprog siman_solve optarg __deregister_frame_info doubleMT fgets germe imod _edata _PROCEDURE_LINKAGE_TABLE_ fopen strcpy _etext _lib_version fflush ntot r1 r2 nv main reloadMT xr12 longres step_siman memcpy _fini eval_cst siman fprintf libm.so.1 SUNW_1.1 libc.so.1 SYSVABI_1.3 libm.so.1 libc.so.1
=' 7̳ Il ` Ih - U ( ^p M _ Z _ _ I 3 I 4 I R I ` I - I 7 I y I 9 J L J h J g J$ # J0 " J< JH k JT V J` b Jl D Jx u J Y @D# @ NE M @ NA @ , @
" @ @ N6 @ N7 㿐 / NX @ # @
$ ?@ ` ` `@ N " 㿐 㿐 / Mʮ㔐 ` ` @ M
㿐 㿈`* @ M "b M"@ M`@ Mې @ M "b M"@ Mޒ`@ M͐ @ Mא "ax M"@ MВa@ M @ Mɐ "a M"@ Ma8@ M @ M "` M"@ MaX@ M O+ ' ) - ' M c. ? ᐰ B !x?@ M M # Bb : !x?@ M M!x ᐖ "? @ M; M h Bx : !x?@ Mx # M c B ᐖ : F!x?@ Mi : h . " M # $Ⱥ % x *L + ĉƑ NN JHD? J @ & ' 2 3 ( ) 2 3ƅȉ LJB? $ @ % 2 3 ( )ąƉ JND? " @ # & ' J? @ ( )P? @ ?@ ` 㿈+ a - / : ? 6: !Ȗa* :
=p=က@ ! " y a,` ( `@ )> # '%#H pHFa " " \ a,` ( ` )> # '%#̀@H pHF
#*`@
`@ J^$c #
?c # Q "@ J@`@ J/ Q!
#! Q @ J7 Q@ J4! # Q cȒ
@ J+!H Q@ J(!h@ J& # Q caƉ >#?cȁ @ p p p p p p p p p p p p p p p p p p p p p p p ( | 4 p p p X p p p p 㿈 !̬ Y ! " . #$@ ې { "hb u # / ) Q3 M̐ $ 3 c ?#` 聩
b # ` ;#`X@ I!̢ @ c !% 1 Q c $ X@ I!̢`@ c >X@ Ia@ IX0 8 !b
0 0bh " + #. 5 % 3 / - Q) & X@ In @ IX #m c `
z !b 㷀 ! $#X R # 7 #!# $bh > R) R #1 D% 5 ; M3 ? @ II? R # RF 聡? B @ I<< $ R 艡 F` D>D d:haX@ I
! Q!X@ I QX@ IaX@ I X@ H QX@ Ha Q X@ Hb R Q #b@D X?@ H R Q #ȒbXD X?@ H a QX@ Hڒbp bX Q@ HԒb QX@ Hϒb QXb@ HȀ Q X0
X0
Q@ Hb QX@ Hb QX@ Hc X@ H" #܀` " @ Ha Q@ H# ( p@ H Q c@ H "l9 ` 5 .7 " Qc@ H a̠ 6 ! #1 R- Q @ H} ( ?@ H @ H à !Ѐ 2 | :# R | % ( (| # # a̒ @ a̖#*``@
" $à 2
| # R "`@ H;@ H* RT H( dà a # R`ȉ B Ƞ' ' '$?(?0 (8Q&+ zbH?@?H?8 ??\ 0 8? @? H? ? #\\@ ## L! Ka̶ K ! *` K ! ! ? ?(?0?8?@ ?H K ! a̔ *`#\#` @ R Xà 4 !Ԁ` 0 h" #` RX@ G`` #8 :`͐ à
#aؔ " "h " ! RX@ G`p R !Ѐ 1a̢ @ #` a̠ , @ 6a̔ #*1 R- $A X @ Gi $$@ Gia 㿐# ! # a̒ @ ̖*``@
"# $á 㿐 # R Ё 㿈 !̔ ?* R @ 聠 B@'@` !̔ &@ 㿐 !̠ % # M, aX@ G
̀ , R㿐! M!@ G # c M@ F"@ F M@ F#(c M@ F#0@ F M@ F#P@ F N@ F @ F @ F 㿐 P@ F#! # P@ Fې# P#@ Fא# 㿐 h 㜀? &4 1 "h"c "o( ( ( ( ( & # "o? &B,"h!!`߲ @ 0 ` @ ` &B,ߺc! @ 0 ` @ `c .@ 0 ' &B,߄ ' 6 'K . .; 6 㿐 ch? "ch !`'K 6 .
. ;
@ 6 #!` n 㿈 ch? "chb a`'K –2 *
*;
@ 2#a`' "# R 艡B R h 㜒`"o* ( ( ( ( "@ ` p\'H` @ E @ E ?H@ F ` cX R@ Eؒ`3 ƀ ??耤 < @ E ƀ ?
` @ Eޔ ? ؉ F?@ E ! ? R@!H 9 @ E ? ?ɔ ` R0 cX@ E @ RcX!@@ E ? (
H @ E @ E @ E 㿐 / E ? ? 㿐 㿠C 㿠 init_cst: xr1: Out of memory
init_cst: xr2: Out of memory
init_cst: xx: Out of memory
init_cst: xs12: Out of memory
init_cst: xr12: Out of memory
? ? ? ? ? %3d
%s:
-------------------------------------------------------------------
Gener Population Cumulated Probability Cumulated
size pop. size of success probability
BC%d %d %d %f %f
Average cumulated population size = %f
%10s: %7d (%4.2f) %9.1f
'%s' calculation of minimal population sizes
in marker-assisted backcross programs
Usage:
%s [options] risk tmax d1 d2
parameters:
d1, d2 distance (in Haldane CentiMorgans, double) from target
gene to 'left' and 'right' markers, resp.; d1 must be
less than or equal to d2 (if not, interchange markers)
tmax maximal duration (in generations, integer)
of backcross program
risk risk (double) of failure of backcross program
(1-risk) = probability of at least one double recombinant
in at most tmax BC generations
printing options:
-h print this help then exit
-d print 'detailed' results (default);
output complete information in a nicely readable fashion
-a print 'abbreviated' results;
outputs only { n[t] (beta[t]) } for t in [1,tmax]
-v verbose mode, prints various intermediate results depending
on optimization options
-f results are put in file ;
otherwise to standard output (default)
breeding scheme options:
-P (double) is the probability of transmission of
the target gene, see references for more details; default .5;
note that prob<.5 implies different meaning for d1 and d2
-I of initial genotype (integer) to start recursion with;
default is 3); possible genotypes at M1-T-M2 are:
1) R-D-D ; 2) D-D-R ; 3) D-D-D
(with M1,M2: left and right markers ; T: target gene ;
R: recipient type allele ; D: donor type allele)
-i same as above, except that genotype is entered
interactively upon request
With no breeding scheme option specified, default is '-P 0.5 -I 3'
population sizes options:
basic options:
-t tests particular population sizes n[t], to be entered
interactively upon request; no optimization performed
just computes probabilities of success for given n[t]
-c 'constant'; minimal population sizes with n[t]=n for all t
-s 'siman'; variable population sizes are computed using the
'simulated annealing' algorithm
-e 'exhaustive'; variable population sizes are computed using an
exhaustive search (could be very long)
additional options:
-r siman search expert option; seed for the ``Mersenne Twister''
random number generator MT19937 used in 'siman' search
-m exhaustive search expert option; lower bound (integer) for
search loops; default is 1
-M exhaustive search expert option; upper bound (integer) for
search loops; default is defined by internal constant IMAX
-p exhaustive search expert option; step size (integer) for
search loops; default is 1
With no population size option specified, default is '-csd'
EXAMPLE:
'popmin -cs .01 3 5.1 10.2'
computes 'constant' and 'siman' minimal populations sizes over
three backcross generations for flanking markers at 5.1 cM and
10.2 cM on each side of target gene, respectively, with an overall
probability of success of .99 over the three generations
REFERENCES:
Hospital F. and Decoux G. (2002) popmin: a program for the numerical
optimization of population sizes in marker-assisted backcross
programs. J. Hered., submitted.
Hospital F. (2001) Size of donor chromosome segments around introgressed
loci and reduction of linkage drag in marker-assisted backcross
programs. Genetics 158: 1363--1379.
Report bugs and comments to Frederic Hospital Usage: %s [options] risk tmax d1 d2
Try '%s -h' for more information.
tcvdahgseim:M:p:r:P:I:f: results will be put in file `%s'
w error cannot open file %s
%s: error: incorrect number of parameters.
%s: error: d2 < d1. Exchange M1 and M2.
=============================================
Reminder: d1 and d2 in CentiMorgans...
chosen values d1 = %f d2 = %f
is this correct? (Warning only)
? @Y Energy : %20.5f %4d %4d
---------------
popmin results:
input parameters:
---------------------------------------------
d1 = %f cM r1 = %f
d2 = %f cM r2 = %f
tmax = %d
risk = %f
P = %f
starting genotype = %d ( M1--T--M2 = R--D--D )
( M1--T--M2 = D--D--R )
( M1--T--M2 = D--D--D )
(M1,M2: left and right markers ; T: target gene)
(R: recipient type allele ; D: donor type allele)
M1 T M2
1) R D D
2) D D R
3) D D D
Enter (unique) genotype to start recurrences with:
%d Population sizes to test:
BC%d: test %s: eval_cst: no solution found for NMAX = %d.
constant siman Exhaustive
bornes: %d %d %d
exhaustive %d %f %d
? ? @Y @$ G ? ? A A #-iter #-evals temperature position energy
%5d %7d %12g %12g
? J K K| KT KP Kp 00 <0 H0 T0 `0 l0 x0 0 0 0 0 0 0 0 0 0 0 0 0 0 4
4
\ o o o 8 8 o o Ip Kx G \ 8 P p 4
4 4 IP
Ip J KP Kl Kt K| K `, & < H W KX e Kl s K } Kt K| KT KP Kh K . K U` 2$ * Kx 7 4D M Kp Z 4< i Kl w 4 K| Uh Up J< Ux p t U| U J0 J$ U U U ( l U `, - U ^p @! IP
4 U ; p G 0 | P U U I \ I a U g U m I t U ( x I | V V - V 4
V h V P 4 Jl 1 d Vh , 0 - T Vl J Vp J ^p @ .x < " _ ' 0 - ( @ 2 I 8 _ = _ @ _ C JT G "P @ R U ! Z J _ _ f KX i K` u _ } 2$ _ 1 J` K\ _ K Ip J J IP 4 JH _ _ _ _ ( $ . ' ` , `$ 4 - | ? Jx F 4 L ,l t U `( [ I popmin crti.s values-Xa.c crtstuff.c __do_global_dtors_aux frame_dummy gcc2_compiled. force_to_data __CTOR_LIST__ object.11 __DTOR_LIST__ __EH_FRAME_BEGIN__ init_dummy completed.4 fini_dummy p.3 popmin.c gcc2_compiled. cokus.c left state gcc2_compiled. y.12 next siman.c gcc2_compiled. crtstuff.c __DTOR_END__ __do_global_ctors_aux __CTOR_END__ gcc2_compiled. force_to_data init_dummy __FRAME_END__ crtn.s s12 betatot getopt xx _start _START_ cst nbar atof atoi epas P b init_cst _environ _end metrique_siman xs12 _iob __register_frame_info _GLOBAL_OFFSET_TABLE_ b_init recur_exhau randomMT tmax atexit exit graph exhau malloc tnv pow xr1 xr2 print_help emax _init test_param risk affiche beta eval_exhau sscanf seedMT emin energie_siman print_siman _END_ test _DYNAMIC fichier printf __iob print_err verb recur eval _exit ener d1 d2 exp exhaustive environ free optind fd nbar_limite nomprog siman_solve optarg __deregister_frame_info doubleMT fgets germe imod _edata _PROCEDURE_LINKAGE_TABLE_ fopen strcpy _etext _lib_version fflush ntot r1 r2 nv main reloadMT xr12 longres step_siman memcpy _fini eval_cst siman fprintf as: WorkShop Compilers 5.0 Alpha 03/27/98 Build
as: WorkShop Compilers 5.0 Alpha 03/27/98 Build
@(#)SunOS 5.7 Generic October 1998 as: WorkShop Compilers 5.0 Alpha 03/27/98 Build
GCC: (GNU) 2.95.2 19991024 (release) as: WorkShop Compilers 5.0 Alpha 03/27/98 Build
GCC: (GNU) 2.95.2 19991024 (release) as: WorkShop Compilers 5.0 Alpha 03/27/98 Build
GCC: (GNU) 2.95.2 19991024 (release) as: WorkShop Compilers 5.0 Alpha 03/27/98 Build
GCC: (GNU) 2.95.2 19991024 (release) as: WorkShop Compilers 5.0 Alpha 03/27/98 Build
GCC: (GNU) 2.95.2 19991024 (release) as: WorkShop Compilers 5.0 Alpha 03/27/98 Build
ld: Software Generation Utilities - Solaris-ELF (4.0) q
< I4 .interp .hash .dynsym .dynstr .SUNW_version .rela.got .rela.bss .rela.plt .text .init .fini .rodata .got .plt .dynamic .data .ctors .dtors .eh_frame .bss .symtab .strtab .comment .stab.index .shstrtab .stab.indexstr values-Xa.c Xt ; O ; V=3.1 ; R=WorkShop Compilers 4.2 30 Oct 1996 C 4.2 /builds3/s998_21a/usr/src/lib/libc/sparc; /opt/SUNWspro.40/SC4.2/bin/../SC4.2/bin/cc -xO3 -xcg89 -Wa,-cg92 -xspace -W0,-Lt -Xt -D_REENTRANT -Dsparc -Iinc -I../inc -DTEXT_DOMAIN='"SUNW_OST_OSLIB"' -I/builds3/s998_21a/proto/root_sparc/usr/include -c -o values-Xa.o ../port/gen/values-Xa.c -W0,-xp t \ \ o @ - 8 8
7 P P 0 A K p p $0 Q 4 4 W 4 4 ] 4 4 e IP IP j Ip Ip $ o J J x KP KP ~ Kl Kl Kt Kt K| K| K K K @ Up c Y \x $ \ ]u q